EFFECTS OF TICLOPIDINE ON PLATELET PROSTAGLANDIN METABOLISM - POSSIBLE CONSEQUENCES FOR PROSTACYCLIN PRODUCTION

被引：32

作者：

LAGARDE, M

GHAZI, I

DECHAYANNE, M

机构：

[1] Inserm U 63, Institut Pasteur, Laboratoire d'Hémobiologie, Lyon, rue Guillaume Paradin

来源：

PROSTAGLANDINS AND MEDICINE | 1979年 / 2卷 / 06期

关键词：

D O I：

10.1016/0161-4630(79)90127-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Ticlopidine, known to inhibit the primary wave of ADP-induced platelet aggregation and to increase the bleeding time, can modify platelet prostaglandin metabolism. The basal level of platelet PGE1 is enhanced by the drug. Ticlopidine does not decrease biosynthesis of prostaglandin endoperoxides from arachidonic acid but increases production of primary prostaglandins, chiefly prostaglandin D2, and causes a slight diminution of thromboxane B2 formation. The excess of prostaglandin endoperoxides not converted to primary prostaglandins may escape from platelets and produce more prostacyclin if endothelial cell microsomes are present in the incubate. © 1979.

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页码：433 / 439

页数：7

相关论文

共 17 条

[1] EFFECT OF TICLOPIDINE AND ACETYLSALICYLIC-ACID ON GENERATION OF PROSTAGLANDIN I2-LIKE SUBSTANCE IN RAT ARTERIAL TISSUE [J].

ASHIDA, SI ;

ABIKO, Y .

THROMBOSIS RESEARCH, 1978, 13 (05) :901-908

[2]

BORN GVR, 1962, NATURE, V194

[3] MECHANISM OF ADENOSINE-DIPHOSPHATE INDUCED PLATELET AGGREGATION - BINDING TO PLATELET RECEPTORS AND INHIBITION OF BINDING AND AGGREGATION BY PROSTAGLANDIN-E1 [J].

BOULLIN, DJ ;

GREEN, AR ;

PRICE, KS .

JOURNAL OF PHYSIOLOGY-LONDON, 1972, 221 (02) :415-&

[4] QUANTITATIVE-DETERMINATION OF PROSTAGLANDINS AND MALONDIALDEHYDE FORMED BY ARACHIDONATE OXYGENASE (PROSTAGLANDIN SYNTHETASE) SYSTEM OF BOVINE SEMINAL VESICLE [J].

FLOWER, RJ ;

CUSHMAN, DW ;

CHEUNG, HS .

PROSTAGLANDINS, 1973, 4 (03) :325-341

[5] DETECTION AND ISOLATION OF AN ENDOPEROXIDE INTERMEDIATE IN PROSTAGLANDIN BIOSYNTHESIS [J].

HAMBERG, M ;

SAMUELSS.B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :899-903

[6] CHEMICAL-STRUCTURE OF PROSTAGLANDIN-X (PROSTACYCLIN) [J].

JOHNSON, RA ;

MORTON, DR ;

KINNER, JH ;

GORMAN, RR ;

MCGUIRE, JC ;

SUN, FF ;

WHITTAKER, N ;

BUNTING, S ;

SALMON, J ;

MONCADA, S ;

VANE, JR .

PROSTAGLANDINS, 1976, 12 (06) :915-928

[7] SIMPLE RADIOCHEMICAL ASSAY OF THROMBOXANE-B2, 12-HYDROXYEICOSATETRAENOIC ACID (HETE) AND 12-HYDROXYHEPTADECATRIENOIC ACID (HHT) SYNTHETIZED BY HUMAN PLATELETS [J].

LAGARDE, M ;

GHARIB, A ;

DECHAVANNE, M .

CLINICA CHIMICA ACTA, 1977, 79 (01) :255-259

[8]

LECRUBIER C, 1977, THERAPIE, V32, P189

[9] VALIDITY OF PG E1 RADIOIMMUNOASSAY BY USING PG E1 ANTISERA WITH DIFFERENTIAL BINDING PARAMETERS [J].

MACLOUF, J ;

ANDRIEU, JM ;

DRAY, F .

FEBS LETTERS, 1975, 56 (02) :273-278

[10] ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION [J].

MONCADA, S ;

GRYGLEWSKI, R ;

BUNTING, S ;

VANE, JR .

NATURE, 1976, 263 (5579) :663-665