SIGNAL-TRANSDUCTION - A TARGET FOR PI(3) KINASE

被引：81

作者：

DOWNWARD, J

机构：

来源：

NATURE | 1995年 / 376卷 / 6541期

关键词：

D O I：

10.1038/376553a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：553 / 554

页数：2

共 16 条

[1] A RETROVIRAL ONCOGENE, AKT, ENCODING A SERINE-THREONINE KINASE CONTAINING AN SH2-LIKE REGION [J].

BELLACOSA, A ;

TESTA, JR ;

STAAL, SP ;

TSICHLIS, PN .

SCIENCE, 1991, 254 (5029) :274-277

[2] EPIDERMAL GROWTH-FACTOR INDUCES PHOSPHORYLATION OF EXTRACELLULAR SIGNAL-REGULATED KINASE-2 VIA MULTIPLE PATHWAYS [J].

BURGERING, BMT ;

DEVRIESSMITS, AMM ;

MEDEMA, RH ;

VANWEEREN, PC ;

TERTOOLEN, LGJ ;

BOS, JL .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (12) :7248-7256

[3] PROTEIN-KINASE-B (C-AKT) IN PHOSPHATIDYLINOSITOL-3-OH INASE SIGNAL-TRANSDUCTION [J].

BURGERING, BMT ;

COFFER, PJ .

NATURE, 1995, 376 (6541) :599-602

[4] MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL PUTATIVE PROTEIN-SERINE KINASE RELATED TO THE CAMP-DEPENDENT AND PROTEIN-KINASE-C FAMILIES [J].

COFFER, PJ ;

WOODGETT, JR .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1991, 201 (02) :475-481

[5] THE INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN OR INSULIN-LIKE GROWTH-FACTOR-1 IN THE RAT SKELETAL-MUSCLE CELL-LINE-L6 IS BLOCKED BY WORTMANNIN, BUT NOT BY RAPAMYCIN - EVIDENCE THAT WORTMANNIN BLOCKS ACTIVATION OF THE MITOGEN-ACTIVATED PROTEIN-KINASE PATHWAY IN L6-CELLS BETWEEN RAS AND RAF [J].

CROSS, DAE ;

ALESSI, DR ;

VANDENHEEDE, JR ;

MCDOWELL, HE ;

HUNDAL, HS ;

COHEN, P .

BIOCHEMICAL JOURNAL, 1994, 303 :21-26

[6]

DATTA K, 1995, MOL CELL BIOL, V15, P2304

[7] SIGNAL-TRANSDUCTION - REGULATING S6 KINASE [J].

DOWNWARD, J .

NATURE, 1994, 371 (6496) :378-379

[8] THE PROTEIN-KINASE ENCODED BY THE AKT PROTOONCOGENE IS A TARGET OF THE PDGF-ACTIVATED PHOSPHATIDYLINOSITOL 3-KINASE [J].

FRANKE, TF ;

YANG, SI ;

CHAN, TO ;

DATTA, K ;

KAZLAUSKAS, A ;

MORRISON, DK ;

KAPLAN, DR ;

TSICHLIS, PN .

CELL, 1995, 81 (05) :727-736

[9] RAS-DEPENDENT INDUCTION OF CELLULAR-RESPONSES BY CONSTITUTIVELY ACTIVE PHOSPHATIDYLINOSITOL-3 KINASE [J].

HU, QJ ;

KLIPPEL, A ;

MUSLIN, AJ ;

FANTL, WJ ;

WILLIAMS, LT .

SCIENCE, 1995, 268 (5207) :100-102

[10] MOLECULAR-CLONING AND IDENTIFICATION OF A SERINE THREONINE PROTEIN-KINASE OF THE 2ND-MESSENGER SUBFAMILY [J].

JONES, PF ;

JAKUBOWICZ, T ;

PITOSSI, FJ ;

MAURER, F ;

HEMMINGS, BA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (10) :4171-4175

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