TETRAZOLE COMPOUNDS .8. SYNTHESIS OF TETRAZOLYLPYRIMIDINES FROM TETRAZOLYL-SUBSTITUTED ENAMINO KETONES

被引:3
作者
FISCHER, GW
机构
[1] KAI e.V, Leipzig, 04303
关键词
D O I
10.1002/jhet.5570300610
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Tetrazolyl-substituted enamino ketones 1 react with various amidines 2 to give 5-(1-phenyl-1H-tetrazol-5-yl)pyrimidines & In the case of the chloroacetyl enamine 4 4-(N,N-dimethylaminomethyl)-substituted tetrazolylpyrimidines 5 were obtained. Subsequent hydrolysis of the 4-trifluoromethyl derivatives 3b, 3d and 3g afforded the corresponding 5-(1-phenyl-1H-tetrazol-5-yl)pyrimidine-4-carboxylic acids 6.
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页码:1517 / 1519
页数:3
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