DISTRIBUTION OF POLYOL - NADP OXIDOREDUCTASE IN MAMMALIAN TISSUES

被引：56

作者：

CLEMENTS, RS

WEAVER, JP

WINEGRAD, AI

机构：

[1] George S. Cox Institute, Department of Medicine University of Pennsylvania, Philadelphia, Pennsylvania

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 37卷 / 02期

关键词：

D O I：

10.1016/0006-291X(69)90741-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Polyol:NADP oxidoreductase and L-gulonate:NADP oxidoreductase in the soluble fraction of rabbit and rat tissues can be separated and identified by a vertical starch-gel electrophoretic technique.The validity of the method was established by comparing the electrophoretic mobilities of partially purified polyol:NADP oxidoreductases and L-gulonate:NADP oxidoreductases with the bands of enzyme activity detected in the soluble fraction of the tissues from which they were isolated. Polyol:NADP oxidoreductase was found to be widely distributed in the tissues of the rabbit and rat; this suggests that polyol synthesis from aldoses may occur in many mammalian tissues. © 1969.

引用

页码：347 / &

共 14 条

[1]

ARSENIS C, 1969, J BIOL CHEM, V244, P3895

[2]

CLEMENTS RL, IN PRESS

[3] SORBITOL PATHWAY - PRESENCE IN NERVE AND CORD WITH SUBSTRATE ACCUMULATION IN DIABETES [J].