PRESSOR REACTIONS TO PSYCHOLOGICAL STRESS AND PREDICTION OF FUTURE BLOOD-PRESSURE - DATA FROM THE WHITEHALL-II STUDY

Objective-To examine whether reactions of blood pressure to future blood pressure. Design-Blood pressure was recorded at a medical screening examination after which presser reactions to a psychological stress task were determined. Follow up measurement of blood pressure was undertaken, on average, 4.9 years later. Setting-20 civil service departments in London. Subjects-1003 male civil servants aged between 35 and 55 years at entry to the study. Main outcome measure-Blood pressure at follow up screening. Results-Reactions of systolic blood pressure to stress correlated positively with systolic blood pressure at follow up screening (r = 0.22, P < 0.01). The dominant correlate of follow up blood pressure was blood pressure at initial screening (r = 0.60 P < 0.01 between initial and follow up systolic blood pressure; r = 0.59, P < 0.01 between initial and follow up diastolic blood pressure). Stepwise multiple regression analysis indicated that reactions to the stressor provided minimal prediction of follow up blood pressure over and above that afforded by blood pressure at initial screening. In the case of follow up systolic blood pressure, systolic reactions to stress accounted for only 1% of follow up variance; systolic blood pressure at initial screening accounted for 34%. With regard to diastolic blood pressure at follow up, the independent contribution from diastolic reactions to stress was less than 1%. Conclusion-Pressor reactions to psychological stress provide minimal independent prediction of blood pressure at follow up. Measurement of reactivity is not a useful clinical index of the course of future blood pressure.