PROCESSED MHC CLASS-I ALLOANTIGEN AS THE STIMULUS FOR CD4+ T-CELL DEPENDENT ANTIBODY-MEDIATED GRAFT-REJECTION

被引：77

作者：

BRADLEY, JA ^{[1
]}

MOWAT, AM ^{[1
]}

BOLTON, EM ^{[1
]}

机构：

[1] WESTERN INFIRM & ASSOCIATED HOSP,DEPT IMMUNOL,GLASGOW G11 6NT,SCOTLAND

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 11期

关键词：

D O I：

10.1016/0167-5699(92)90069-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The traditional view of graft rejection is one of direct recognition of allogeneic MHC molecules by effector T cells, the phenotype of which may be predicted by the nature of the MHC disparity. In this article, Andrew Bradley and colleagues discuss recent evidence that suggests this view may be an oversimplification, and argue that additional effector mechanisms, such as alloantibody, need to be reconsidered.

引用

页码：434 / 438

页数：5

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