THE HUMAN GENOME PROJECT - PROSPECTS AND IMPLICATIONS FOR CLINICAL MEDICINE

被引:30
作者
GREEN, ED
WATERSTON, RH
机构
[1] WASHINGTON UNIV, SCH MED, DEPT PATHOL, ST LOUIS, MO 63110 USA
[2] WASHINGTON UNIV, SCH MED, DEPT INTERNAL MED, ST LOUIS, MO 63110 USA
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1991年 / 266卷 / 14期
关键词
D O I
10.1001/jama.266.14.1966
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The recently initiated human genome project is a large international effort to elucidate the genetic architecture of the genomes of man and several model organisms. The initial phases of this endeavor involve the establishment of rough blueprints (maps) of the genetic landscape of these genomes, with the long-term goal of determining their precise nucleotide sequences and identifying the genes. The knowledge gained by these studies will provide a vital tool for the study of many biologic processes and will have a profound impact on clinical medicine.
引用
收藏
页码:1966 / 1975
页数:10
相关论文
共 77 条
[1]   THE MAPPING AND SEQUENCING OF THE HUMAN GENOME [J].
ANTONARAKIS, SE .
SOUTHERN MEDICAL JOURNAL, 1990, 83 (08) :876-878
[2]   DIAGNOSIS OF GENETIC-DISORDERS AT THE DNA LEVEL [J].
ANTONARAKIS, SE .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 320 (03) :153-163
[3]   THE NF1 LOCUS ENCODES A PROTEIN FUNCTIONALLY RELATED TO MAMMALIAN GAP AND YEAST IRA PROTEINS [J].
BALLESTER, R ;
MARCHUK, D ;
BOGUSKI, M ;
SAULINO, A ;
LETCHER, R ;
WIGLER, M ;
COLLINS, F .
CELL, 1990, 63 (04) :851-859
[4]   GENETIC-LINKAGE MAP OF HUMAN CHROMOSOME-7 WITH 63 DNA MARKERS [J].
BARKER, D ;
GREEN, P ;
KNOWLTON, R ;
SCHUMM, J ;
LANDER, E ;
OLIPHANT, A ;
WILLARD, H ;
AKOTS, G ;
BROWN, V ;
GRAVIUS, T ;
HELMS, C ;
NELSON, C ;
PARKER, C ;
REDIKER, K ;
RISING, M ;
WATT, D ;
WEIFFENBACH, B ;
DONISKELLER, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (22) :8006-8010
[5]   GENE-MAPPING AND CYSTIC-FIBROSIS [J].
BARKER, PE .
AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 1990, 299 (01) :69-72
[6]   ISOLATION AND CHARACTERIZATION OF YEAST ARTIFICIAL CHROMOSOME CLONES LINKING THE HLA-B AND HLA-C LOCI [J].
BRONSON, SK ;
PEI, J ;
TAILLONMILLER, P ;
CHORNEY, MJ ;
GERAGHTY, DE ;
CHAPLIN, DD .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) :1676-1680
[7]   CLONING OF LARGE SEGMENTS OF EXOGENOUS DNA INTO YEAST BY MEANS OF ARTIFICIAL CHROMOSOME VECTORS [J].
BURKE, DT ;
CARLE, GF ;
OLSON, MV .
SCIENCE, 1987, 236 (4803) :806-812
[8]   ORCHESTRATING THE HUMAN GENOME PROJECT [J].
CANTOR, CR .
SCIENCE, 1990, 248 (4951) :49-51
[9]  
CARLE GF, 1985, P NATL ACAD SCI USA, V82, P3576
[10]   TOWARD A PHYSICAL MAP OF THE GENOME OF THE NEMATODE CAENORHABDITIS-ELEGANS [J].
COULSON, A ;
SULSTON, J ;
BRENNER, S ;
KARN, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (20) :7821-7825