EXPANDED DISTRIBUTION OF MESSENGER-RNA FOR NERVE GROWTH-FACTOR, BRAIN-DERIVED NEUROTROPHIC FACTOR, AND NEUROTROPHIN-3 IN THE RAT-BRAIN AFTER COLCHICINE TREATMENT

被引:124
作者
CECCATELLI, S
ERNFORS, P
VILLAR, MJ
PERSSON, H
HOKFELT, T
机构
[1] KAROLINSKA INST,DEPT MED CHEM,MOLEC NEUROBIOL LAB,S-10401 STOCKHOLM 60,SWEDEN
[2] INST NEUROBIOL,BUENOS AIRES,ARGENTINA
关键词
NEUROTROPHIC FACTOR; REGULATION; LOCALIZATION; INSITU HYBRIDIZATION;
D O I
10.1073/pnas.88.22.10352
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The effect of intracerebroventricular injection of the mitosis inhibitor colchicine on expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin 3 was studied in the rat brain with in situ hybridization. Colchicine up-regulates mRNA for NGF and BDNF in many of the neuronal systems normally expressing these factors. In addition, after colchicine treatment NGF and BDNF mRNAs were localized in several brain areas where they normally cannot be detected. Thus, NGF MRNA was present, for example, in many motor nuclei and in the basal forebrain, and BDNF mRNA was seen in many nuclei in the brain stem and in catecholamine neurons, including dopamine neurons in the substantia nigra. The latter neurons have recently been shown to be sensitive to BDNF, and the present results show that these neurons can produce this factor themselves. A decrease in mRNA for BDNF and neurotrophin 3 was seen only in the granular-cell layer of the hippocampal formation. A strong hybridization signal for BDNF and neurotrophin 3 mRNA was also observed over several myelinated tracts in treated rats, supporting the hypothesis that glial cells as well as neurons can produce these trophic factors.
引用
收藏
页码:10352 / 10356
页数:5
相关论文
共 50 条
[1]   EXPRESSION OF THE BETA-NERVE GROWTH-FACTOR GENE IN HIPPOCAMPAL-NEURONS [J].
AYERLELIEVRE, C ;
OLSON, L ;
EBENDAL, T ;
SEIGER, A ;
PERSSON, H .
SCIENCE, 1988, 240 (4857) :1339-1341
[2]  
BALLARIN M, 1991, IN PRESS EXP NEUROL
[3]   PURIFICATION OF A NEW NEUROTROPHIC FACTOR FROM MAMMALIAN BRAIN [J].
BARDE, YA ;
EDGAR, D ;
THOENEN, H .
EMBO JOURNAL, 1982, 1 (05) :549-553
[4]   LRF PRODUCING CELLS OF MAMMALIAN HYPOTHALAMUS - FLUORESCENT-ANTIBODY STUDY [J].
BARRY, J ;
DUBOIS, MP ;
POULAIN, P .
ZEITSCHRIFT FUR ZELLFORSCHUNG UND MIKROSKOPISCHE ANATOMIE, 1973, 146 (03) :351-366
[5]   EXPRESSION OF C-FOS IMMUNOREACTIVITY IN TRANSMITTER-CHARACTERIZED NEURONS AFTER STRESS [J].
CECCATELLI, S ;
VILLAR, MJ ;
GOLDSTEIN, M ;
HOKFELT, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9569-9573
[6]   EFFECTS OF CENTRAL-NERVOUS-SYSTEM LESIONS ON THE EXPRESSION OF GALANIN - A COMPARATIVE INSITU HYBRIDIZATION AND IMMUNOHISTOCHEMICAL STUDY [J].
CORTES, R ;
VILLAR, MJ ;
VERHOFSTAD, A ;
HOKFELT, T .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7742-7746
[7]   DIFFERENTIAL-EFFECTS OF INTRACEREBROVENTRICULAR COLCHICINE ADMINISTRATION ON THE EXPRESSION OF MESSENGER-RNAS FOR NEUROPEPTIDES AND NEUROTRANSMITTER ENZYMES, WITH SPECIAL EMPHASIS ON GALANIN - AN INSITU HYBRIDIZATION STUDY [J].
CORTES, R ;
CECCATELLI, S ;
SCHALLING, M ;
HOKFELT, T .
SYNAPSE, 1990, 6 (04) :369-391
[8]   EFFECT OF COLCHICINE ON TRANSPORT OF AMINE STORAGE GRANULES IN SYMPATHETIC NERVES OF RAT [J].
DAHLSTROM, A .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1968, 5 (01) :111-+
[9]   EXPRESSION OF NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IS DEVELOPMENTALLY REGULATED AND INCREASED AFTER AXOTOMY IN RAT SPINAL-CORD MOTONEURONS [J].
ERNFORS, P ;
HENSCHEN, A ;
OLSON, L ;
PERSSON, H .
NEURON, 1989, 2 (06) :1605-1613
[10]   MOLECULAR-CLONING AND NEUROTROPHIC ACTIVITIES OF A PROTEIN WITH STRUCTURAL SIMILARITIES TO NERVE GROWTH-FACTOR - DEVELOPMENTAL AND TOPOGRAPHICAL EXPRESSION IN THE BRAIN [J].
ERNFORS, P ;
IBANEZ, CF ;
EBENDAL, T ;
OLSON, L ;
PERSSON, H .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5454-5458