MOVEMENT OF INTERNALIZED LIGAND RECEPTOR COMPLEXES ALONG A CONTINUOUS ENDOSOMAL RETICULUM

被引：387

作者：

HOPKINS, CR

GIBSON, A

SHIPMAN, M

MILLER, K

机构：

[1] Department of Biochemistry, Imperial College

来源：

NATURE | 1990年 / 346卷 / 6282期

关键词：

D O I：

10.1038/346335a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Complexes of cell-surface receptors and their ligands are commonly internalized by endocytosis and enter a prelysosomal endosomal pathway for further processing. Fluorescence microscopy and video recording of living cells to trace the passage of ligand-receptor complexes has identified the endosomal compartment as an extensive network of tubular cisternae. Endocytosed material entering this reticulum enters discrete swellings, identified as multivesicular bodies by electron microscopy, which move along the reticulum towards the pericentriolar area. © 1990 Nature Publishing Group.

引用

页码：335 / 339

页数：5

共 24 条

[1]

BEARDMORE J, 1987, J CELL SCI, V87, P495

[2]

BELLOT F, 1990, J CELL BIOL, V56, P829

[3] TUBULOVESICULAR PROCESSES EMERGE FROM TRANS-GOLGI CISTERNAE, EXTEND ALONG MICROTUBULES, AND INTERLINK ADJACENT TRANS-GOLGI ELEMENTS INTO A RETICULUM [J].