THE EFFECT OF GM-CSF AND G-CSF ON HUMAN NEUTROPHIL FUNCTION

被引:74
作者
BOBER, LA
GRACE, MJ
PUGLIESESIVO, C
ROJASTRIANA, A
WATERS, T
SULLIVAN, LM
NARULA, SK
机构
[1] Schering-Plough Research Institute, Department of Immunology, Kenilworth, NJ 07033
来源
IMMUNOPHARMACOLOGY | 1995年 / 29卷 / 02期
关键词
GM-CSF; G-CSF; NEUTROPHIL; CYTOKINE;
D O I
10.1016/0162-3109(94)00050-P
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A direct comparison of GM-CSF and G-CSF in a panel of in vitro neutrophil-function assays was performed to investigate any differences in activity profiles. In our modified chemotactic assay, GM-CSF rapidly increased the migratory capacity of polymorphonuclear cells (PMNs) to move toward fMLP and LTB(4). In contrast, G-CSF only stimulated PMN migration towards fMLP. GM-CSF, but not G-CSF, increased PMN cytotoxic killing of C. albicans blastospores. The expression of PMN surface antigens associated with Fc- and complement-mediated cell-binding (Fc gamma R1, CR-1 and CR-3), and adhesion signalling (ICAM-1), was increased after the exposure of GM-CSF, but not to G-CSF. In contrast these CSFs demonstrated relative equipotency in their ability to induce PMN anti-bacterial phagocytosis, and to restore the Staphylococcus aureus killing capacity of dexamethasone-suppressed neutrophils. The phagocytic activity of PMNs for opsonized yeast, as well as hexose-monophosphate shunt activity, was equivalent following GM-CSF or G-CSF treatment. We discuss the significance of the difference in activity profiles in this article.)
引用
收藏
页码:111 / 119
页数:9
相关论文
共 38 条
[1]  
BACH MC, 1973, TRANSPL P, V5, P549
[2]  
BAECHNER R, 1968, NEW ENGL J MED, V278, P971
[3]   EVALUATION OF A FLUOROCHROME ASSAY FOR ASSESSING THE BACTERICIDAL ACTIVITY OF NEUTROPHILS IN HUMAN PHAGOCYTE DYSFUNCTIONS [J].
BELLINATIPIRES, R ;
MELKI, SE ;
COLLETTO, GMDD ;
CARNEIROSAMPAIO, MMS .
JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 119 (02) :189-196
[4]   INVITRO AND INVIVO ANALYSIS OF THE EFFECTS OF RECOMBINANT HUMAN GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS [J].
BRONCHUD, MH ;
POTTER, MR ;
MORGENSTERN, G ;
BLASCO, MJ ;
SCARFFE, JH ;
THATCHER, N ;
CROWTHER, D ;
SOUZA, LM ;
ALTON, NK ;
TESTA, NG ;
DEXTER, TM .
BRITISH JOURNAL OF CANCER, 1988, 58 (01) :64-69
[5]  
BUESCHER ES, 1988, J INFECT DIS, V158, P1140
[6]  
CECH P, 1984, BLOOD, V64, P147
[7]  
CROSIER PS, 1992, SEMIN ONCOL, V19, P349
[8]   A SIMPLE AND INEXPENSIVE METHOD FOR ASSESSING INVITRO CANDIDACIDAL ACTIVITY OF LEUKOCYTES [J].
CUTLER, JE ;
THOMPSON, BD .
JOURNAL OF IMMUNOLOGICAL METHODS, 1984, 66 (01) :27-33
[9]   IMPAIRED NEUTROPHIL FUNCTION IN PATIENTS WITH AIDS OR AIDS-RELATED COMPLEX - A COMPREHENSIVE EVALUATION [J].
ELLIS, M ;
GUPTA, S ;
GALANT, S ;
HAKIM, S ;
VANDEVEN, C ;
TOY, C ;
CAIRO, MS .
JOURNAL OF INFECTIOUS DISEASES, 1988, 158 (06) :1268-1276
[10]   PURIFIED HUMAN GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR - DIRECT ACTION ON NEUTROPHILS [J].
GASSON, JC ;
WEISBART, RH ;
KAUFMAN, SE ;
CLARK, SC ;
HEWICK, RM ;
WONG, GG ;
GOLDE, DW .
SCIENCE, 1984, 226 (4680) :1339-1342