BIDIRECTIONAL CYTOKINE INTERACTIONS IN THE MATERNAL-FETAL RELATIONSHIP - IS SUCCESSFUL PREGNANCY A TH2 PHENOMENON

被引：2415

作者：

WEGMANN, TG

LIN, H

GUILBERT, L

MOSMANN, TR

机构：

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 07期

关键词：

D O I：

10.1016/0167-5699(93)90235-D

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Pregnant females are susceptible to intracellular pathogens and are biased towards humoral rather than cell-mediated immunity. Since T(H)1 cytokines compromise pregnancy and T(H)2 cytokines are produced at the maternal-fetal interface, we hypothesize that these T(H)2 cytokines inhibit T(H)1 responses, improving fetal survival but impairing responses against some pathogens.

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页码：353 / 356

页数：4

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