INVOLVEMENT OF PROTEIN-KINASE-C IN THE DELAYED CYTOPROTECTION FOLLOWING SUBLETHAL ISCHEMIA IN RABBIT MYOCARDIUM

被引：141

作者：

BAXTER, GF

GOMA, FM

YELLON, DM

机构：

[1] UCL HOSP, HATTER INST CARDIOVASC STUDIES, DIV CARDIOL, LONDON WC1E 6DB, ENGLAND

[2] UCL, SCH MED, HATTER INST CARDIOVASC STUDIES, DIV CARDIOL, LONDON WC1E 6DB, ENGLAND

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1995年 / 115卷 / 02期

基金：

英国惠康基金;

关键词：

ISCHEMIC PRECONDITIONING; 2ND WINDOW OF PROTECTION; MYOCARDIAL PROTECTION; ISCHEMIA; INFARCTION; PROTEIN KINASE C (PKC); CHELERYTHRINE;

D O I：

10.1111/j.1476-5381.1995.tb15866.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rabbit hearts were preconditioned with four 5 min coronary artery occlusions 24 h before 30 min coronary occlusion with 120 min reperfusion. Preconditioning significantly reduced the percentage of myocardium infarcting within the risk zone from 49.1 +/- 4.3% to 31.8 +/- 3.5% (P < 0.05). When the protein kinase C (PKC) inhibitor, chelerythrine, was administered just before preconditioning, the delayed protection against infarction 24 h later was abolished. We conclude that the delayed cytoprotective response associated with ischaemic preconditioning of myocardium is likely to involve the early activation of one or more PKC subtypes.

引用

收藏

页码：222 / 224

页数：3

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