REDUCED SENSITIVITY OF THE N-METHYL-D-ASPARTATE COMPONENT OF SYNAPTIC TRANSMISSION TO MAGNESIUM IN HIPPOCAMPAL SLICES FROM IMMATURE RATS

被引：100

作者：

MORRISETT, RA

MOTT, DD

LEWIS, DV

WILSON, WA

SWARTZWELDER, HS

机构：

[1] DUKE UNIV,DEPT PEDIAT NEUROL,DURHAM,NC 27710

[2] DUKE UNIV,DEPT MED NEUROL,DURHAM,NC 27710

[3] DUKE UNIV,DEPT PSYCHOL,DURHAM,NC 27706

[4] DUKE UNIV,DEPT PHARMACOL,DURHAM,NC 27710

来源：

DEVELOPMENTAL BRAIN RESEARCH | 1990年 / 56卷 / 02期

关键词：

6,7-Dinitroquinoxaline-2,3-dione; Development; Excitatory amino acid; Hippocampus; Magnesium; N-Methyl-d-aspartate; Ontogeny; Picrotoxin;

D O I：

10.1016/0165-3806(90)90090-L

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study describes the measurement of N-methyl-d-aspartate (NMDA)-mediated excitatory postsynaptic potentials (EPSPs) of the CA1 subregion of transverse hippocampal slices from immature and adult rats. Our methods permit extracellular measurement of NMDA-mediated depolarizations in the presence of magnesium (Mg2+) ions. In comparison to slices from adult rats (75-90 days old), NMDA EPSPs in hippocampus from immature rats (25-35 days old) were of significantly greater amplitude and were significantly less sensitive to magnesium. It is suggested that developmental plasticity may be related to changes in magnesium regulation of the NMDA channel complex. © 1990.

引用

页码：257 / 262

页数：6

共 32 条

[1] EFFECTS OF NEW NON-N-METHYL-D-ASPARTATE ANTAGONISTS ON SYNAPTIC TRANSMISSION IN THE INVITRO RAT HIPPOCAMPUS [J].