ASPIRIN-LIKE DRUGS INTERFERE WITH ARACHIDONATE METABOLISM BY INHIBITION OF THE 12-HYDROPEROXY-5,8,10,14-EICOSATETRAENOIC ACID PEROXIDASE-ACTIVITY OF THE LIPOXYGENASE PATHWAY

被引：237

作者：

SIEGEL, MI

MCCONNELL, RT

CUATRECASAS, P

机构：

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.3774

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Aspirin, indomethacin, and sodium salicylate are anti-inflammatory, analgesic, and antipyretic. Whereas aspirin and indomethacin inhibit prostaglandin synthetase (cyclo-oxygenase; 8, 11, 14-eicosatrienoate, hydrogen-donor: oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. However, all three drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid.

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页码：3774 / 3778

页数：5

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