EFFECT OF ALPHA-DIFLUOROMETHYLORNITHINE, AN ENZYME-ACTIVATED IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE, ON POLYAMINE LEVELS IN RAT TISSUES

被引：139

作者：

DANZIN, C

JUNG, MJ

GROVE, J

BEY, P

机构：

[1] Centre de Recherche Merrell International, 67084 Strasbourg Cedex, 16, rue d'Ankara

来源：

LIFE SCIENCES | 1979年 / 24卷 / 06期

关键词：

D O I：

10.1016/0024-3205(79)90173-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

α-Difluoromethylornithine (RMI 71.782), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (E.C. 4.1.1.17) in vitro, causes a rapid, long-lasting, dose-dependent decrease of ornithine decarboxylase activity in prostate and, to a lesser extent, in thymus and testis of rats when injected intraperitoneally. Repeated doses (100 mg/kg or 1 g/kg) of α-difluoromethylornithine given to rats for two weeks markedly decreased polyamine concentrations in several rat tissues and selectively slowed down growth of ventral prostate and of thymus. © 1979.

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页码：519 / 524

页数：6

相关论文

共 16 条

[1] ORNITHINE DECARBOXYLASE AND HISTAMINASE (DIAMINE OXIDASE) ACTIVITIES IN RAT THYMUS AND THEIR RELATIONSHIP TO THYMUS LYMPHOCYTE [J].

ATKINS, FL ;

BEAVEN, MA .

BIOCHEMICAL PHARMACOLOGY, 1975, 24 (07) :763-768

[2] POLYAMINE LEVELS IN NORMAL HUMAN-SERUM - COMPARISON OF ANALYTICAL METHODS [J].

BARTOS, F ;

BARTOS, D ;

GRETTIE, DP ;

CAMPBELL, RA ;

MARTON, LJ ;

SMITH, RG ;

DAVES, GD .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1977, 75 (04) :915-919

[3] INCREASED CELLULAR LEVELS OF SPERMIDINE OR SPERMINE ARE REQUIRED FOR OPTIMAL DNA-SYNTHESIS IN LYMPHOCYTES ACTIVATED BY CONCANAVALIN A [J].

FILLINGAME, RH ;

JORSTAD, CM ;

MORRIS, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4042-4045

[4]

INOUE H, 1975, J BIOCHEM, V77, P879, DOI 10.1093/oxfordjournals.jbchem.a130796

[5] POLYAMINES IN RAPID GROWTH AND CANCER [J].

JANNE, J ;

POSO, H ;

RAINA, A .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 473 (3-4) :241-293

[6] HORMONAL REGULATION OF SPERMIDINE FORMATION DURING SPERMATOGENESIS IN RAT [J].

MACINDOE, JH ;

TURKINGTON, RW .

ENDOCRINOLOGY, 1973, 92 (02) :595-605

[7] ALPHA-METHYL ORNITHINE, A POTENT COMPETITIVE INHIBITOR OF ORNITHINE DECARBOXYLASE, BLOCKS PROLIFERATION OF RAT HEPATOMA-CELLS IN CULTURE [J].

MAMONT, PS ;

BOHLEN, P ;

MCCANN, PP ;

BEY, P ;

SCHUBER, F ;

TARDIF, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (05) :1626-1630

[8] AUTOMATED MICROMETHOD FOR QUANTITATIVE-ANALYSIS OF DIAMINES AND POLYAMINES UTILIZING A SENSITIVE HIGH-PRESSURE LIQUID-CHROMATOGRAPHIC PROCEDURE [J].

MARTON, LJ ;

HEBY, O ;

WILSON, CB ;

LEE, PLY .

FEBS LETTERS, 1974, 41 (01) :99-103

[9] CATALYTIC IRREVERSIBLE INHIBITION OF MAMMALIAN ORNITHINE DECARBOXYLASE (E C 4 1 1 17) BY SUBSTRATE AND PRODUCT ANALOGS [J].

METCALF, BW ;

BEY, P ;

DANZIN, C ;

JUNG, MJ ;

CASARA, P ;

VEVERT, JP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (08) :2551-2553

[10] STUDIES ON ORNITHINE DECARBOXYLASE FROM LIVER OF THIOACETAMIDE-TREATED RATS - PURIFICATION AND SOME PROPERTIES [J].

ONO, M ;

SUZUKI, F ;

TAKEDA, Y ;

INOUE, H .

BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 284 (01) :285-&