INDUCTION OF THE ANTIOXIDANT STRESS PROTEINS HEME OXYGENASE-1 AND MSP23 BY STRESS AGENTS AND OXIDIZED LDL IN CULTURED VASCULAR SMOOTH-MUSCLE CELLS

被引：80

作者：

SIOW, RCM

ISHII, T

SATO, H

TAKETANI, S

LEAKE, DS

SWEIRY, JH

PEARSON, JD

BANNAI, S

MANN, GE

机构：

[1] UNIV LONDON KINGS COLL,DIV BIOMED SCI,VASC BIOL RES CTR,PHYSIOL GRP,LONDON W8 7AH,ENGLAND

[2] UNIV TSUKUBA,INST BASIC MED SCI,DEPT BIOCHEM,TSUKUBA,IBARAKI 305,JAPAN

[3] KANSAI MED UNIV,DEPT HYG,OSAKA 570,JAPAN

[4] UNIV READING,SCH ANIM & MICROBIAL SCI,READING RG6 2AJ,BERKS,ENGLAND

来源：

FEBS LETTERS | 1995年 / 368卷 / 02期

关键词：

SMOOTH MUSCLE CELL; HEME OXYGENASE-1; MSP23; OXIDATIVE STRESS PROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; ATHEROSCLEROSIS;

D O I：

10.1016/0014-5793(95)00650-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Enhanced expression of the antioxidant stress proteins heme oxygenase-1 (HO-1) and macrophage stress protein (MSP23) by oxidative stress agents and oxidatively modified low density lipoproteins (LDL) was investigated in cultured porcine aortic smooth muscle cells, Treatment of smooth muscle cells with glucose oxidase, CdCl2 or diethylmaleate resulted in a time-dependent (6-48 h) induction of HO-1 and MSP23 expression, Exposure of cells to 100 mu g protein/ml highly oxidised LDL increased the expression of HO-1 and MSP23 within 24 h, and the induction was dependent on the degree of LDL oxidation, The induction of HO-1 and MSP23 may thus play an important cytoprotective role against oxidative stress in atherogenesis.

引用

页码：239 / 242

页数：4

共 26 条

[1] CLONING AND SEQUENCING OF THIOL-SPECIFIC ANTIOXIDANT FROM MAMMALIAN BRAIN - ALKYL HYDROPEROXIDE REDUCTASE AND THIOL-SPECIFIC ANTIOXIDANT DEFINE A LARGE FAMILY OF ANTIOXIDANT ENZYMES [J].