IN-SITU DETECTION OF DNA FRAGMENTATION AFTER FOCAL CEREBRAL-ISCHEMIA IN MICE

被引：115

作者：

LI, Y

CHOPP, M

JIANG, N

ZALOGA, C

机构：

[1] HENRY FORD HLTH SCI CTR, CTR STROKE RES, DETROIT, MI 48202 USA

[2] OAKLAND UNIV, DEPT PHYS, ROCHESTER, MI 48309 USA

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 28卷 / 01期

关键词：

DNA FRAGMENTATION; APOPTOSIS; TRANSIENT MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE;

D O I：

10.1016/0169-328X(94)00220-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brains from 5 mice subjected to focal ischemia (2 hours) - reperfusion (22 h), revealed a significant increase (P < 0.01) in cells exhibiting DNA fragmentation (100-200 per section) - ipsilateral hemisphere compared to 0-3 per section found in the contralateral hemisphere and normal (n = 5) and sham operated (n = 5) mice. Neurons were the predominant cells (90-95%) exhibiting DNA fragmentation, and were primarily located in the inner boundary zone to the infarct. Apoptosis may contribute to the development of infarct after transient focal cerebral ischemia.

引用

页码：164 / 168

页数：5

共 21 条

[1] THRESHOLDS IN CEREBRAL-ISCHEMIA - THE ISCHEMIC PENUMBRA [J].