HEPATIC LIPASE MAY ACT AS A LIGAND IN THE UPTAKE OF ARTIFICIAL CHYLOMICRON REMNANT-LIKE PARTICLES BY ISOLATED RAT HEPATOCYTES

被引：85

作者：

DIARD, P

MALEWIAK, MI

LAGRANGE, D

GRIGLIO, S

机构：

[1] INST BIOMED CORDELIERS, INSERM, U177, PHYSIOPATHOL NUTR LAB, F-75006 PARIS, FRANCE

[2] CONSERVATOIRE NATL ARTS & METIERS, CHAIRE BIOL, F-75003 PARIS, FRANCE

来源：

BIOCHEMICAL JOURNAL | 1994年 / 299卷

关键词：

D O I：

10.1042/bj2990889

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Active and heat-inactivated hepatic lipase stimulated to a statistically comparable extent the uptake of chylomicron remnant-like particles by isolated rat hepatocytes by 3-fold and 2.3-fold respectively and, likewise, their binding to hepatic plasma membranes by 5-fold and 4-fold respectively. Hepatic lipase may facilitate uptake of these particles, not only as a lipolytic enzyme, but also as a ligand anchored to extracellular glycosaminoglycans.

引用

页码：889 / 894

页数：6

共 47 条

[1]

BARTLETT GR, 1959, J BIOL CHEM, V234, P466

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