EFFECTS OF AMINO-ACIDS ON CALCIUM-UPTAKE BY GLIAL AND NEUROBLASTOMA-CELLS

被引：6

作者：

BORG, J ^{[1
]}

MARK, J ^{[1
]}

MANDEL, P ^{[1
]}

机构：

[1] INST CHIM BIOL,STRASBOURG,FRANCE

来源：

JOURNAL OF NEUROBIOLOGY | 1979年 / 10卷 / 01期

关键词：

D O I：

10.1002/neu.480100104

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The uptake of [45Ca] has been studied in clonal glial and neuronal cells. It was somewhat more efficient in the neuroblastoma clone M1 compared to glial clones. In all cases [45Ca] uptake was shown to depend on the phosphate concentration in the incubation medium. It was decreased by the ionophore A 23187 at 200 μM concentration in both neuronal and glial clones. The influence of amino acids some of which are putative neurotransmitters was investigated; the interactions between [45Ca] uptake and these amino acids were related to their concentration and the type of cells used (neuronal or glial). L‐aspartate and taurine for example had two opposite effects on [45Ca] uptake by the glial clone NN at two different concentrations; they could therefore play a role in the control of calcium level in the synaptic cleft. Copyright © 1979 John Wiley & Sons, Inc.

引用

页码：31 / 40

页数：10

共 20 条

[1]

BABCOCK DF, 1976, J BIOL CHEM, V251, P3881

[2] HIGH AFFINITY UPTAKE OF L-GLUTAMATE AND L-ASPARTATE BY GLIAL CELLS [J].