ROLE OF HIPPOCAMPAL CHOLINERGIC MECHANISMS IN ACQUISITION OF A BARPRESS RESPONSE

被引：15

作者：

JAFFARD, R

EBEL, A

DESTRADE, C

AYAD, G

MANDEL, P

CARDO, B

机构：

[1] UNIV BORDEAUX 1, INST BIOL ANIM, PSYCHOPHYSIOL LAB, F-33405 TALENCE, FRANCE

[2] CNRS, CTR NEUROCHIM, F-67000 STRASBOURG, FRANCE

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1976年 / 5卷 / 03期

关键词：

D O I：

10.1016/0091-3057(76)90092-7

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The role of hippocampal cholinergic mechanisms in learning a bar-press response reinforced with food was investigated. An interstrain comparison showed that mice having a low choline acetyltransferase activity in the dorsal hippocampus were quicker to associate the barpress with reinforcement. When the activity of this enzyme was reduced by a subseizure electrical stimulation of the hippocampus learning was accelerated. It is suggested that acetylcholine availability at the hippocampal synapses slowed the appearance of these learned responses.

引用

页码：371 / 374

页数：4

共 23 条

[1] ANALYSIS OF FACILITATION OF AVOIDANCE ACQUISITION PRODUCED BY D-AMPHETAMINE AND SCOPOLAMINE [J].