NEURODEVELOPMENTAL EVENTS UNDERLYING INFORMATION ACQUISITION AND STORAGE

被引：19

作者：

DOYLE, E ^{[1
]}

NOLAN, P ^{[1
]}

BELL, R ^{[1
]}

REGAN, CM ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,DEPT PSYCHOL,BELFAST BT7 1NN,ANTRIM,NORTH IRELAND

来源：

NETWORK-COMPUTATION IN NEURAL SYSTEMS | 1992年 / 3卷 / 01期

关键词：

D O I：

10.1088/0954-898X/3/1/010

中图分类号：

TP18 [人工智能理论];

学科分类号：

081104 ; 0812 ; 0835 ; 1405 ;

摘要：

This brief overview presents evidence to suggest that information storage, in part, may be based on synapse connectivity changes mediated by a replay of neurodevelopmental events. These considerations are based on studies which have monitored change in neural cell adhesion molecule (NCAM) sialylation state during acquisition and consolidation of a passive avoidance response in the adult rat. The synapse-specific isoform of NCAM. NCAM180, is demonstrated to increase sialylation state in the hippocampus between 12-24 h after training and to produce a novel sialylated form of 210 kDa. Interventive studies with specific antibodies showed NCAM to play a specific role at 6-8 h after training, the amnestic effect of which does not become apparent until the process of NCAM sialylation is complete.

引用

页码：89 / 94

页数：6

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