VINBLASTINE-INDUCED PRECIPITATION OF MICROTUBULE PROTEIN

被引：191

作者：

MARANTZ, R

VENTILLA, M

SHELANSK.M

机构：

[1] Departments of Pathology and Pharmacology, Albert Einstein College of Medicine, Bronx

[2] Department of Chemistry, Columbia University, New York

来源：

SCIENCE | 1969年 / 165卷 / 3892期

关键词：

D O I：

10.1126/science.165.3892.498

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vinblastine quantitatively precipitates a protein from supernatants obtained from high-speed centrifugation of homogenates of HeLa cells and of pig brain. This protein migrates as a single band on gel electrophoresis, has a mobility identical to that of purified microtubule protein, and-like microtubule protein-binds colchicine. The precipitation is partially inhibited by 0.9 percent NaCl.

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页码：498 / &

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