BIOCHEMICAL CHARACTERIZATION OF BETA-CHAIN VARIANT HAPTOGLOBIN MARBURG

被引：12

作者：

CLEVE, H

BOWMAN, BH

GORDON, S

机构：

[1] Department of Medicine, Cornell University Medical College, New York

[2] Department of Human Genetics, University of Texas Medical Branch, Galveston, Texas The Rockefeller University, New York

来源：

HUMANGENETIK | 1969年 / 7卷 / 04期

关键词：

D O I：

10.1007/BF00283555

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

β-chains were isolated from two individuals heterozygous for the β-chain mutant haptoglobin Marburg. Total amino acid composition and tryptic peptides were compared with β-chains from common haptoglobin types. ββMb chain preparations are characterized by the presence of β-chains with an atypical electrophoretic migration rate and by at least three, possibly four additional peptides in their tryptic digests. It is probable that haptoglobin Marburg is the result of an mutational event other than a single base substitution. © 1969 Springer-Verlag.

引用

页码：337 / &

共 11 条

[1]

Beuing H, 1965, Z Hyg Infektionskr, V151, P291, DOI 10.1007/BF02154229

[2]

CHEFTEL RI, 1966, CR ACAD SCI D NAT, V262, P1982

[3]

CHOI YM, 1967, THESIS CATHOLIC MEDI, V13, P277

[4] SO-CALLED HAPTOGLOBIN-MARBURG - A RARE HEREDITARY VARIANT HAPTOGLOBIN WITH 2 DIFFERENT PHENOTYPES IN THE SAME FAMILY [J].