THE NEUROBIOLOGY OF STRESS-ULCERS

被引：118

作者：

GLAVIN, GB

MURISON, R

OVERMIER, JB

PARE, WP

BAKKE, HK

HENKE, PG

HERNANDEZ, DE

机构：

[1] UNIV MANITOBA, DEPT SURG, WINNIPEG R3E 0W3, MANITOBA, CANADA

[2] UNIV BERGEN, DEPT BIOL & MED PSYCHOL, N-5005 BERGEN, NORWAY

[3] UNIV MINNESOTA, DEPT PSYCHOL, MINNEAPOLIS, MN 55455 USA

[4] VET ADM MED CTR, EASTERN RES & DEV OFF, PERRY POINT, MD 21902 USA

[5] ST FRANCIS XAVIER UNIV, NEUROSCI LAB, ANTIGONISH B2G 1C0, NS, CANADA

[6] UNIV SO CALIF, SCH MED,GASTROENTEROL SECT, LOS ANGELES, CA 90033 USA

来源：

BRAIN RESEARCH REVIEWS | 1991年 / 16卷 / 03期

关键词：

BRAIN-GUT AXIS; CORTICOTROPIN-RELEASING FACTOR; DOPAMINE; LIMBIC SYSTEM; NEUROBIOLOGY; NEUROPEPTIDE-Y; NORADRENALINE; PSYCHOLOGICAL STRESS; STRESS; THYROTROPIN-RELEASING HORMONE; ULCER;

D O I：

10.1016/0165-0173(91)90012-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have reviewed the neurobiology of stress ulcers from animal models to potential pharmacotherapeutic mechanisms. The evidence strongly supports the hypothesis that certain stress-related gastric lesions are 'braindriven' events which may be more effectively managed through central manipulations than by altering local, gastric factors. Recent advances in the use of anxiolytic and antidepressant drugs in the management of stress-related gastric mucosal injury further supports the contention that a brain-gut axis, which may have nervous, peptidergic and classic monoaminergic components, modulates the intricate and complicated pattern of communication between the brain and the stomach. Delineation of the precise pathways which make up this communication as well as their manipulation by various pharmacological agents will be the focus of future research endeavour. © 1991.

引用

页码：301 / 343

页数：43

共 535 条

[1] PREDICTABLE AND UNPREDICTABLE SHOCK - BEHAVIORAL MEASURES OF AVERSION AND PHYSIOLOGICAL MEASURES OF STRESS [J].