REGULATION OF APOPTOSIS IN THE IMMUNE-SYSTEM

被引：323

作者：

KRAMMER, PH ^{[1
]}

BEHRMANN, I ^{[1
]}

DANIEL, P ^{[1
]}

DHEIN, J ^{[1
]}

DEBATIN, KM ^{[1
]}

机构：

[1] UNIV HEIDELBERG, CHILDRENS HOSP, W-6900 HEIDELBERG, GERMANY

来源：

CURRENT OPINION IN IMMUNOLOGY | 1994年 / 6卷 / 02期

关键词：

D O I：

10.1016/0952-7915(94)90102-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Apoptosis in T and B lymphocytes is involved in all fundamental processes in the immune system. It is a mechanism to regulate the course of an immune response and to establish immunological memory as well as central and peripheral tolerance. Apoptosis in lymphocytes is regulated by gene products that induce or block this process. Elucidating the molecular basis for sensitivity and resistance towards induction of apoptosis is the key to the understanding of the development of the immune system, basic immune reactions and the pathogenesis of autoimmune diseases, AIDS and cancer.

引用

页码：279 / 289

页数：11

共 154 条

[1] ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE [J].

ADACHI, M ;

WATANABEFUKUNAGA, R ;

NAGATA, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1756-1760

[2] A POSSIBLE ROLE FOR BCL-2 IN REGULATING T-CELL MEMORY - A BALANCING ACT BETWEEN CELL-DEATH AND SURVIVAL [J].

AKBAR, AN ;

SALMON, M ;

SAVILL, J ;

JANOSSY, G .

IMMUNOLOGY TODAY, 1993, 14 (11) :526-532

[3] THE SIGNIFICANCE OF LOW BCL-2 EXPRESSION BY CD45RO-T-CELLS IN NORMAL INDIVIDUALS AND PATIENTS WITH ACUTE VIRAL-INFECTIONS - THE ROLE OF APOPTOSIS IN T-CELL MEMORY [J].

AKBAR, AN ;

BORTHWICK, N ;

SALMON, M ;

GOMBERT, W ;

BOFILL, M ;

SHAMSADEEN, N ;

PILLING, D ;

PETT, S ;

GRUNDY, JE ;

JANOSSY, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :427-438

[4] FAS TRANSDUCES ACTIVATION SIGNALS IN NORMAL HUMAN T-LYMPHOCYTES [J].

ALDERSON, MR ;

ARMITAGE, RJ ;

MARASKOVSKY, E ;

TOUGH, TW ;

ROUX, E ;

SCHOOLEY, K ;

RAMSDELL, F ;

LYNCH, DH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2231-2235

[5]

ALES MJ, 1992, EUR J IMMUNOL, V22, P845

[6] DIFFERENCES DEFINED BY BONE-MARROW TRANSPLANTATION SUGGEST THAT LPR AND GLD ARE MUTATIONS OF GENES ENCODING AN INTERACTING PAIR OF MOLECULES [J].

ALLEN, RD ;

MARSHALL, JD ;

ROTHS, JB ;

SIDMAN, CL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (05) :1367-1375

[7] MOLECULAR AND BIOLOGICAL CHARACTERIZATION OF A MURINE LIGAND FOR CD40 [J].

ARMITAGE, RJ ;

FANSLOW, WC ;

STROCKBINE, L ;

SATO, TA ;

CLIFFORD, KN ;

MACDUFF, BM ;

ANDERSON, DM ;

GIMPEL, SD ;

DAVISSMITH, T ;

MALISZEWSKI, CR ;

CLARK, EA ;

SMITH, CA ;

GRABSTEIN, KH ;

COSMAN, D ;

SPRIGGS, MK .

NATURE, 1992, 357 (6373) :80-82

[8]

ARTAGLIA LA, 1993, CELL, V74, P845

[9] CROSS-LINKING CD4 BY HUMAN IMMUNODEFICIENCY VIRUS-GP120 PRIMES T-CELLS FOR ACTIVATION-INDUCED APOPTOSIS [J].

BANDA, NK ;

BERNIER, J ;

KURAHARA, DK ;

KURRLE, R ;

HAIGWOOD, N ;

SEKALY, RP ;

FINKEL, TH .

JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (04) :1099-1106

[10] CELL-DEATH BY APOPTOSIS IN ACUTE-LEUKEMIA [J].

BAXTER, GD ;

COLLINS, RJ ;

HARMON, BV ;

KUMAR, S ;

PRENTICE, RL ;

SMITH, PJ ;

LAVIN, MF .

JOURNAL OF PATHOLOGY, 1989, 158 (02) :123-129

← 1 2 3 4 5 6 7 8 9 10 →