MOLECULAR-CLONING OF MAST-CELL GROWTH-FACTOR, A HEMATOPOIETIN THAT IS ACTIVE IN BOTH MEMBRANE-BOUND AND SOLUBLE FORMS

被引：899

作者：

ANDERSON, DM

LYMAN, SD

BAIRD, A

WIGNALL, JM

EISENMAN, J

RAUCH, C

MARCH, CJ

BOSWELL, HS

GIMPEL, SD

COSMAN, D

WILLIAMS, DE

机构：

[1] VET ADM MED CTR,INDIANAPOLIS,IN 46223

[2] IMMUNEX CORP,DEPT EXPTL HEMATOL,SEATTLE,WA 98101

[3] IMMUNEX CORP,DEPT PROT CHEM,SEATTLE,WA 98101

来源：

CELL | 1990年 / 63卷 / 01期

关键词：

D O I：

10.1016/0092-8674(90)90304-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously reported the identification of a novel mast cell growth factor (MGF) that was shown to be a ligand for c-kit and is encoded by a gene that maps near the steel locus on mouse chromosome 10. We now report the cloning of cDNAs encoding the MGF protein. The MGF protein encoded by this cDNA can be expressed in a biologically active form as either a membrane bound protein or as a soluble factor. The soluble protein promotes the proliferation of MGF-responsive cell lines and, in the presence of erythropoietin, stimulates the formation of macrocytic erythroid and multilineage hematopoietic colonies. © 1990.

引用

页码：235 / 243

页数：9

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