REGIONAL DISTRIBUTION OF METHIONINE-ENKEPHALIN AND BETA-ENDORPHIN-LIKE IMMUNOREACTIVITY IN HUMAN-BRAIN AND PITUITARY

被引：162

作者：

GRAMSCH, C

HOLLT, V

MEHRAEIN, P

PASI, A

HERZ, A

机构：

[1] HANOVER UNIV MED,DEPT NEUROPATHOL,D-3000 HANOVER,FED REP GER

[2] UNIV ZURICH,GERICHTLICH MED INST,CH-8028 ZURICH,SWITZERLAND

来源：

BRAIN RESEARCH | 1979年 / 171卷 / 02期

关键词：

D O I：

10.1016/0006-8993(79)90332-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Concentrations of methionine-enkephalin- (Met-enkephalin) and β-endorphin immunoreactivities were determined in 33 areas of human brain and pituitary using highly sensitive radioimmunassays with affinity chromatography for the purification of β-endorphin. It was found that they have quite different distribution patterns, suggesting the existence of both endorphins in independent systems in the central nervous system. Determination of Met-enkephalin and immunoreactivities in chronic alcoholics and opiate-dependent subjects revealed no gross changes in comparison to the normal subjects. © 1979.

引用

页码：261 / 270

页数：10

共 25 条

[1] NEURONS CONTAINING BETA-ENDORPHIN IN RAT-BRAIN EXIST SEPARATELY FROM THOSE CONTAINING ENKEPHALIN - IMMUNOCYTOCHEMICAL STUDIES [J].