The emerging role of MIF in septic shock and infection

被引：40

作者：

Bernhagen, J

Calandra, T

Bucala, R

机构：

[1] The Picower Institute for Medical Research, Manhassett, New York

来源：

BIOTHERAPY | 1995年 / 8卷 / 02期

关键词：

MIF septic shock; infection; cytokines; pituitary endotoxin;

D O I：

10.1007/BF01878495

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The protein mediator described originally as macrophage migration inhibitory factor (MIF) has been ''re-discovered'' recently to be both a novel pituitary hormone and a pro-inflammatory, macrophage-derived cytokine. Emerging studies indicate that MIF plays a pivotal role not only in endotoxic shock but also in the host response to a variety of acute and chronic infections.

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收藏

页码：123 / 127

页数：5

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