HEMOGLOBINS A AND A2 IN NEW WORLD PRIMATES - COMPARATIVE VARIATION AND ITS EVOLUTIONARY IMPLICATIONS

被引：38

作者：

BOYER, SH

CROSBY, EF

THURMON, TF

NOYES, AN

FULLER, GF

LESLIE, SE

SHEPARD, MK

HERNDON, CN

机构：

[1] Division of Medical Genetics, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore

[2] Department of Preventive Medicine and Genetics, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem

[3] Facultad de Medicina, Universidad Peruana Cayetano Heredia, Lima

[4] Department of Pediatrics, Louisiana State University, School of Medicine, New Orleans

来源：

SCIENCE | 1969年 / 166卷 / 3911期

关键词：

D O I：

10.1126/science.166.3911.1428

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hemoglobin A2 (α2δ2) in New World primates represents about 1/160 to 1/16 of total hemoglobin and, by virtue of this low proportion, is presumed to be functionally unimportant. Nonetheless, A2 exhibits genetic polymorphism by electrophoresis in three out of five genera, whereas the major component, hemoglobin A (α2β2), is electrophoretically invariant. Moreover, in four genera, including man, the evolutionary accumulation of mutations has been greater in δ than in β. Such findings suggest that both polymorphism and evolutionary changes can accrue to an effectively functionless and thus selectively nearly neutral gene.

引用

页码：1428 / &

共 23 条

[1]

[Anonymous], 1969, ATLAS PROTEIN SEQ ST

[2]

BOYER SH, 1963, AM J HUM GENET, V15, P438

[3]

BOYER SH, IN PRESS

[4] ABNORMAL HUMAN HAEMOGLOBINS - SEPARATION AND CHARACTERIZATION OF ALPHA AND BETA CHAINS BY CHROMATOGRAPHY AND DETERMINATION OF 2 NEW VARIANTS HB CHESAPEAKE AND HB J (BANGKOK) [J].