GAMMA-COP, A COAT SUBUNIT OF NON-CLATHRIN-COATED VESICLES WITH HOMOLOGY TO SEC21P

被引：53

作者：

STENBECK, G

SCHREINER, R

HERRMANN, D

AUERBACH, S

LOTTSPEICH, F

ROTHMAN, JE

WIELAND, FT ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST BIOCHEM 1,NEUENHEIMER FELD 328,W-6900 HEIDELBERG,GERMANY

[2] SLOAN KETTERING MEM CANC CTR,ROCKERFELLER RES LAB,NEW YORK,NY 10021

[3] MAX PLANCK INST BIOCHEM,GENZENTRUM,W-8033 MARTINSRIED,GERMANY

来源：

FEBS LETTERS | 1992年 / 314卷 / 02期

关键词：

ENDOPLASMIC RETICULUM; GOLGI; VESICULAR TRANSPORT; COATOMER; SEC21; COAT PROTEIN GAMMA-COP;

D O I：

10.1016/0014-5793(92)80973-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Constitutive secretory transport in eukaryotes is likely to be mediated by non-clathrin-coated vesicles, which have been isolated and characterized [(1989) Cell 58, 329-336; (1991) Nature 349, 215-220]. They contain a set of coat proteins (COPs) which are also likely to exist in a preformed cytosolic complex named coatomer [(1991) Nature 349, 248-250]. From peptide sequence and cDNA structure comparisons evidence is presented that one of the subunits of coatomer, gamma-COP, is a true constituent of non-clathrin-coated vesicles, and that gamma-COP is related to sec 21, a secretory mutant of the yeast Saccharomyces cervisiae.

引用

页码：195 / 198

页数：4

共 20 条

[1] RECONSTITUTION OF THE TRANSPORT OF PROTEIN BETWEEN SUCCESSIVE COMPARTMENTS OF THE GOLGI MEASURED BY THE COUPLED INCORPORATION OF N-ACETYLGLUCOSAMINE [J].