HUMAN LUNG MAST-CELL AND ALVEOLAR MACROPHAGE CYTOPLASMIC LIPID BODIES CONTAIN ARACHIDONIC-ACID AND PROSTAGLANDIN ENDOPEROXIDE SYNTHASE (CYCLOOXYGENASE), THE SUBSTRATE AND ENZYME NECESSARY FOR PROSTAGLANDIN PRODUCTION

被引：18

作者：

DVORAK, AM

SCHLEIMER, RP

DVORAK, HF

LICHTENSTEIN, LM

WELLER, PF

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,JOHNS HOPKINS ASTHMA & ALLERGY CTR,DIV CLIN IMMUNOL,BALTIMORE,MD 21205

[2] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[3] BETH ISRAEL HOSP,CHARLES A DANA RES INST,BOSTON,MA 02215

[4] BETH ISRAEL HOSP,DEPT MED,BOSTON,MA 02215

[5] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02115

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1992年 / 99卷 / 2-4期

关键词：

MAST CELL; MACROPHAGE; LIPID BODIES; ARACHIDONIC ACID; CYCLOOXYGENASE; PROSTAGLANDIN; ULTRASTRUCTURE; AUTORADIOGRAPHY; IMMUNOCYTOCHEMISTRY; SUBCELLULAR FRACTIONATION;

D O I：

10.1159/000236250

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Lipid bodies are non-membrane-bound cytoplasmic organelles that are prevalent in mammalian cells of diverse lineages and that have been observed to increase in cells involved in inflammatory responses. Specialized morphological and biochemical studies have provided evidence for the involvement of lipid bodies in eicosanoid synthesis.

引用

页码：208 / 217

页数：10

共 29 条

[1] PROSTAGLANDIN ENDOPEROXIDE SYNTHASE - REGULATION OF ENZYME EXPRESSION [J].