CONTROL OF DEGRADATION AND SYNTHESIS OF INDUCED TYROSINE AMINOTRANSFERASE STUDIED IN HEPATOMA CELLS IN CULTURE

被引：71

作者：

AURICCHI.F

MARTIN, D

TOMKINS, G

机构：

[1] Laboratory of Molecular Biology, National Institute of Arthritis and Metabolic Diseases, Bethesda, MD

[2] Istituto de Patologia Generale, Dell'Universita de Napoli, Napoli

[3] Department of Medicine, University of California Medical Center, San Francisco

[4] Department of Biochemistry, University of California Medical Center, San Francisco

来源：

NATURE | 1969年 / 224卷 / 5221期

关键词：

D O I：

10.1038/224806b0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

WE have been studying the mechanism of tyrosine amino-transferase (TAT) induction by adrenal steroids in hepatoma (HTC) cell cultures1,2. The hormones increase the rate of enzyme synthesis resulting in an increased intracellular TAT concentration3. The enzyme is continuously turning over with a half-time of degradation of 3 to 7 h (measured as loss of either enzymic or antigenic activity), depending on the experiment and the conditions. © 1969 Nature Publishing Group.

引用

页码：806 / &

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