CILIARY NEUROTROPHIC FACTOR PREVENTS DEGENERATION OF ADULT-RAT SUBSTANTIA-NIGRA DOPAMINERGIC-NEURONS IN-VIVO

被引：214

作者：

HAGG, T

VARON, S

机构：

[1] Department of Biology, University of California, San Diego

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 13期

关键词：

NEURONAL DEATH; AXOTOMY; TROPHIC FACTOR; TYROSINE HYDROXYLASE; PARKINSON DISEASE;

D O I：

10.1073/pnas.90.13.6315

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have investigated the neuroprotective effects of recombinant human ciliary neurotrophic factor (CNTF) for injured dopaminergic neurons of the adult rat substantia nigra compacta. Fourteen days after a unilateral transection of the nigrostriatal pathway two-thirds of the neurons (identified by retrograde labeling) had degenerated. In sharp contrast, 73% (a few cases, >90%) of this cell loss was prevented by continuous infusion of CNTF close to the injured neurons. However, CNTF did not prevent the disappearance of the transmitter-synthesizing enzyme tyrosine hydroxylase. Thus, CNTF has potent neurotrophic effects for injured adult rat dopaminergic substantia nigra neurons, whose degeneration plays a major causative role in Parkinson disease.

引用

页码：6315 / 6319

页数：5

共 58 条

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