CONCENTRATION OF TOBRAMYCIN IN BRONCHIAL-SECRETIONS

被引：29

作者：

ALEXANDER, MR

BERGLUND, EM

KASIK, JE

FOX, A

CHINN, WM

机构：

[1] UNIV IOWA,COLL PHARM,IOWA CITY,IA 52242

[2] UNIV IOWA,COLL MED,DEPT INTERNAL MED,IOWA CITY,IA 52242

[3] VET ADM HOSP,DEPT MICROBIOL,IOWA CITY,IA 52240

来源：

CHEST | 1979年 / 75卷 / 06期

关键词：

D O I：

10.1378/chest.75.6.675

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Fifteen noninfected patients received three consecutive doses of tobramycin (1.7 mg/kg intramuscularly). Serum and bronchial secretions were obtained during bronchoscopy. Microbiologic assay demonstrated that bronchial secretions containing tobramycin produced inappropriately small zone sizes when compared with serum. Also, it was shown that bronchial secretions frequently do achieve therapeutic concentrations of tobramycin at this dosage level and route of administration.

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页码：675 / 678

页数：4

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