REPLICATION OF AVIAN INFLUENZA-VIRUSES IN HUMANS

被引：248

作者：

BEARE, AS

WEBSTER, RG

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT VIROL & MOLEC BIOL, 332 N LAUDERDALE, MEMPHIS, TN 38105 USA

[2] HARVARD HOSP, CLIN RES CTR, SALISBURY, WILTS, ENGLAND

来源：

ARCHIVES OF VIROLOGY | 1991年 / 119卷 / 1-2期

关键词：

D O I：

10.1007/BF01314321

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Volunteers inoculated with avian influenza viruses belonging to subtypes currently circulating in humans (H1N1 and H3N2) were largely refractory to infection. However 11 out of 40 volunteers inoculated with the avian subtypes, H4N8, H6N1, and H10N7, shed virus and had mild clinical symptoms: they did not produce a detectable antibody response. This was presumably because virus multiplication was limited and insufficient to stimulate a detectable primary immune response. Avian influenza viruses comprise hemagglutinin (HA) subtypes 1-14 and it is possible that HA genes not so far seen in humans could enter the human influenza virus gene pool through reassortment between avian and circulating human viruses.

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页码：37 / 42

页数：6

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