IDENTIFICATION OF 2 MESSENGER PPAR RELATED RECEPTORS AND EVIDENCE FOR THE EXISTENCE OF 5 SUBFAMILY MEMBERS

被引：140

作者：

CHEN, F ^{[1
]}

LAW, SW ^{[1
]}

OMALLEY, BW ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT CELL BIOL,1 BAYLOR PLAZA,HOUSTON,TX 77030

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two additional forms of mouse peroxisome proliferator activated receptor have been identified from cDNA libraries derived from mouse tissues using a low stringency cross-hybridization screening method. One is mNUCI, which has 97% amino acid sequence identity with hNUCI in its DNA binding domain. The other one is mPPARγ. The full-length cDNA of mPPARγ encodes a protein of 470 amino acids in length. The overall amino acid sequence identity is 75% as compared with xPPARγ, with the highest homology in the DNA binding region and ligand binding region, 97% and 86% identity, respectively. The ry of two new forms of mPPAR and the recent cloning of hPPAR provide evidence for the existence of at least five different forms of receptor in the peroxisome proliferator activated receptor subfamily. © 1993 Academic Press, Inc.

引用

页码：671 / 677

页数：7

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