2-CHLOROADENOSINE 5'-PHOSPHATE AND 2-CHLOROADENOSINE 5'-DIPHOSPHATE PHARMACOLOGICALLY ACTIVE NUCLEOTIDE ANALOGS

2-Chloroadenosine 5′-phosphate and diammonium 2-chloroadenoisine 5′-diphosphate have been synthesized, and isolated analytically pure. Their effects on the in vitro aggregation of sheep platelets in platelet-rich plasma and on rat arterial blood pressure were compared with those of adenosine, 2-chloroadenosine, adenosine 5′-phosphate (AMP), and adenosine 5′-diphosphate (ADP). 2-Chloroadenosine 5′-phosphate (2-chloro-AMP) inhibited the ADP-mediated aggregation of sheep platelets and was initially equipotent with AMP and was longer acting: 2-chloro-AMP was a more potent and longer acting vasodepressor than AMP. 2-Chloroadenosine 5′-diphosphate (2-chloroADP) was of similar potency to ADP as a vasodepressor and was longer acting: 2-chloro-ADP reversibly aggregated sheep platelets and was nine times as potent as ADP. © 1969, American Chemical Society. All rights reserved.