DISAPPEARANCE OF GAD-MESSENGER RNA AND TYROSINE-HYDROXYLASE IN SUBSTANTIA-NIGRA FOLLOWING STRIATAL IBOTENIC ACID LESIONS - EVIDENCE FOR TRANSNEURONAL REGRESSION

被引：41

作者：

PASINETTI, GM ^{[1
]}

MORGAN, DG ^{[1
]}

FINCH, CE ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

EXPERIMENTAL NEUROLOGY | 1991年 / 112卷 / 02期

关键词：

D O I：

10.1016/0014-4886(91)90063-I

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Transneuronal regression in substantia nigra reticulata (SNR) and substantia nigra compacta (SNC) neurons was studied in Fischer 344 male rats by immunocytochemistry and by in situ hybridization. Three months after striatal lesioning by ibotenic acid, there was a shrinkage (30%) of the SNR region cross-sectional area and a 50% disappearance of neurons that contain glutamic acid decarboxylase (GAD)-mRNA, but only in the ventromedial portion of this nucleus. Loss of dopaminergic neurons, as recognized by tyrosine hydroxylase immunoreactivity, occurred only in caudal portions of the SNC and SNR. These findings suggest that lasions in reciprocally connected pathways, like the nigrostriatal and striatonigral systems, may produce a vicious cycle (feedforward cascade) of neurodegeneration due to interference with retrograde and anterograde influences. © 1991.

引用

页码：131 / 139

页数：9

共 30 条

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