ARACHIDONIC-ACID INDUCED DEGRANULATION OF RABBIT PERITONEAL NEUTROPHILS

被引：100

作者：

NACCACHE, PH ^{[1
]}

SHOWELL, HJ ^{[1
]}

BECKER, EL ^{[1
]}

SHAAFI, RI ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT PHYSIOL,FARMINGTON,CT 06032

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 87卷 / 01期

关键词：

D O I：

10.1016/0006-291X(79)91678-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have found that arachidonic acid rapidly and selectively induces the release of lysosomal enzymes from cytochalasin B treated rabbit peritoneal neutrophils. 5, 8, 11, 14-eicosatetraynoic acid inhibits the arachidonate induced release with an apparent KD of 1.5 × 10-6M. 5,8,11,14-eicosatetraynoic acid (2.5 × 10-5M also inhibits the chemotactic factors and the A23187 induced release in the presence of cytochalasin B but does not affect the degranulation induced by A23187 alone. These observations strongly suggest a role for arachidonate metabolites in rabbit neutrophil physiology. © 1979.

引用

页码：292 / 299

页数：8

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