ENHANCED CONSTRICTION OF THE PERIPHERAL LARGE ARTERY IN RESPONSE TO ACUTE INDUCTION OF A LOW-FLOW STATE IN HUMAN HYPERCHOLESTEROLEMIA

被引:25
作者
FILITTI, V [1 ]
GIRAL, P [1 ]
SIMON, A [1 ]
MERLI, I [1 ]
DELPINO, M [1 ]
LEVENSON, J [1 ]
机构
[1] HOP BROUSSAIS,INSERM,CTR DIAGNOST,96 RUE DIDOT,F-75674 PARIS 14,FRANCE
来源
ARTERIOSCLEROSIS AND THROMBOSIS | 1991年 / 11卷 / 01期
关键词
LARGE-ARTERY DIAMETER; BLOOD VELOCITY; PULSED DOPPLER FLOW METER; BLOOD FLOW; HYPERCHOLESTEROLEMIA; FLOW-MEDIATED VASOCONSTRICTION;
D O I
10.1161/01.ATV.11.1.161
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The diameter, blood velocity, and blood flow of the brachial artery were evaluated with a pulsed-Doppler apparatus before and after wrist occlusion in 16 normocholesterolemic and 27 hypercholesterolemic male subjects of similar age and body mass index. Before occlusion, no hemodynamic differences were observed between the two groups. Occlusion significantly reduced blood velocity and blood flow in the two groups (p < 0.001), but such reductions were not different between hypercholesterolemic and normocholesterolemic groups. Occlusion decreased the arterial diameter in the hypercholesterolemic group only (p < 0.001), and absolute diameter changes after occlusion were significantly different between the two groups (p <0.001). No correlation was found between the change in arterial diameter after occlusion and the baseline diameter before occlusion in the normocholesterolemic and hypercholesterolemic population overall. Absolute and percent diameter changes after occlusion were correlated with total cholesterol (r = - 0.73, r = - 0.72; p < 0.001) and with low density lipoprotein (LDL) cholesterol (r = - 0.68, r = - 0.69; p < 0.001) in the normocholesterolemic and hypercholesterolemic population overall, respectively. These findings indicate that the low-flow state induces a reduction in large-artery diameter in the hypercholesterolemic but not in the normocholesterolemic state and is closely related to the degree of elevation of blood cholesterol and of its LDL fraction.
引用
收藏
页码:161 / 166
页数:6
相关论文
共 19 条
[1]   FLOW-MEDIATED AND REFLEX CHANGES IN LARGE PERIPHERAL ARTERY TONE IN HUMANS [J].
ANDERSON, EA ;
MARK, AL .
CIRCULATION, 1989, 79 (01) :93-100
[2]   HEMODYNAMIC SEQUELAE OF REGRESSION OF EXPERIMENTAL ATHEROSCLEROSIS [J].
ARMSTRONG, ML ;
HEISTAD, DD ;
MARCUS, ML ;
PIEGORS, DJ ;
ABBOUD, FM .
JOURNAL OF CLINICAL INVESTIGATION, 1983, 71 (01) :104-113
[3]  
ARMSTRONG ML, 1985, ARTERIOSCLEROSIS, V5, P335
[4]   REVERSAL OF ATHEROSIS AND SCLEROSIS - THE 2 COMPONENTS OF ATHEROSCLEROSIS [J].
BLANKENHORN, DH ;
KRAMSCH, DM .
CIRCULATION, 1989, 79 (01) :1-7
[5]  
DRAPER N, 1960, APPLIED REGRESSION A, P10
[6]  
ELLEFSON RD, 1982, FUNDAMENTALS CLIN CH, P509
[7]  
HARRISON DG, 1987, CIRC RES, V61, P74
[8]   DIETARY-TREATMENT OF ATHEROSCLEROSIS ABOLISHES HYPERRESPONSIVENESS TO SEROTONIN - IMPLICATIONS FOR VASOSPASM [J].
HEISTAD, DD ;
MARK, AL ;
MARCUS, ML ;
PIEGORS, DJ ;
ARMSTRONG, ML .
CIRCULATION RESEARCH, 1987, 61 (03) :346-351
[9]   REACTIVE DILATION OF LARGE CORONARY-ARTERIES IN CONSCIOUS DOGS [J].
HINTZE, TH ;
VATNER, SF .
CIRCULATION RESEARCH, 1984, 54 (01) :50-57
[10]   BRACHIAL ARTERIAL CHANGES IN RESPONSE TO WRIST OCCLUSION IN NORMOTENSIVE AND HYPERTENSIVE MEN [J].
LEVENSON, J ;
SIMON, A ;
PITHOISMERLI, I .
AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (02) :H217-H224