SELECTIVE ACTIVATION OF HUMAN BETA-GLOBIN BUT NOT GAMMA-GLOBIN GENE IN HUMAN FIBROBLASTXMOUSE ERYTHROLEUKEMIA CELL HYBRIDS

被引：88

作者：

WILLING, MC

NIENHUIS, AW

ANDERSON, WF

机构：

[1] Laboratory of Molecular Hematology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda

来源：

NATURE | 1979年 / 277卷 / 5697期

关键词：

D O I：

10.1038/277534a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human α- and β-globin genes have been activated in MEL times; human fibroblast cell hybrids. However, even though the human γ- and β-globin genes are closely linked and were shown in these hybrid clones to be present in approximately equal numbers, no human γ-globin mRNA was produced. Thus, the human β- and γ-globin genes in these cells are differentially regulated apparently by a positive regulatory factor(s) specific for individual globin genes. © 1979 Nature Publishing Group.

引用

页码：534 / 538

页数：5

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