RAPID RISE IN CYCLIC-GMP ACCOMPANIES CATECHOLAMINE SECRETION IN SUSPENSIONS OF ISOLATED ADRENAL CHROMAFFIN CELLS

被引：61

作者：

SCHNEIDER, AS

CLINE, HT

LEMAIRE, S

机构：

[1] CORNELL UNIV,GRAD SCH MED SCI,NEW YORK,NY 10021

[2] UNIV SHERBROOKE,SCH MED,DEPT PHARMACOL,SHERBROOKE J1K 2R1,QUEBEC,CANADA

来源：

LIFE SCIENCES | 1979年 / 24卷 / 15期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

D O I：

10.1016/0024-3205(79)90009-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Acetylcholine stimulates a five-fold increase in cyclic GMP within seconds of addition to suspensions of isolated adrenal chromaffin cells. The rapid kinetics and dose-response curve for cyclic GMP accumulation are compared with corresponding results for catecholamine secretion and a possible role of cyclic GMP in stimulus-secretion coupling is considered. © 1979.

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页码：1389 / 1394

页数：6

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