DISSOCIATION OF NITROVASODILATOR-INDUCED RELAXATION FROM CYCLIC-GMP LEVELS DURING INVITRO NITRATE TOLERANCE

被引：36

作者：

KOWALUK, EA ^{[1
]}

FUNG, HL ^{[1
]}

机构：

[1] SUNY BUFFALO, SCH PHARM, DEPT PHARMACEUT, 517 HOCHSTETTER HALL, BUFFALO, NY 14260 USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 176卷 / 01期

关键词：

cGMP; Nitrate tolerance; Nitric oxide; Nitroglycerin; S-Nitroso-N-acetylpenicillamine; S-Nitrosothiols;

D O I：

10.1016/0014-2999(90)90136-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effects of nitroglycerin tolerance on relaxation and cyclic GMP accumulation by nitroglycerin, nitric oxide and S-nitroso-N-acetylpenicillamine were examined in isolated rate aortic rings. Cyclic GMP accumulation by nitroglycerin, S-nitroso-N-acetylpenicillamine and nitric oxide was diminished in nitroglycerin-tolerant aorta. In contrast, only relaxation by nitroglycerin, but not S-nitroso-N-acetylpenicillamine and nitric oxide, was attenuated. These data suggest that cyclic GMP levels might represent an inadequate index for mechanistic studies of nitroglycerin relaxation tolerance. © 1990.

引用

页码：91 / 95

页数：5

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