ENZYMATIC-SYNTHESIS OF SIALYL LEX AND DERIVATIVES BASED ON A RECOMBINANT FUCOSYL-TRANSFERASE

被引：41

作者：

DUMAS, DP

ICHIKAWA, Y

WONG, CH

LOWE, JB

NAIR, RP

机构：

[1] Scripps Res Inst, DEPT CHEM, LA JOLLA, CA 92037 USA

[2] UNIV MICHIGAN, MED CTR, HOWARD HUGHES MED INST, ANN ARBOR, MI 48109 USA

[3] UNIV MICHIGAN, MED CTR, DEPT PATHOL, ANN ARBOR, MI 48109 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 08期

关键词：

D O I：

10.1016/S0960-894X(00)80270-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A recombinant human Lewis alpha(1,3/1,4)fucosyltransferase has been studied for its acceptor substrate specificity and used in the synthesis of sialyl Le(x) and derivatives.

引用

页码：425 / 428

页数：4

共 9 条

[1]

FUKOWSKALATALLO JF, 1990, GENE DEV, V4, P1288

[2]

KAMEYAMA A, 1991, CARBOHYD RES, V209, pC1

[3] ELAM-1-DEPENDENT CELL-ADHESION TO VASCULAR ENDOTHELIUM DETERMINED BY A TRANSFECTED HUMAN FUCOSYL-TRANSFERASE CDNA [J].

LOWE, JB ;

STOOLMAN, LM ;

NAIR, RP ;

LARSEN, RD ;

BERHEND, TL ;

MARKS, RM .

CELL, 1990, 63 (03) :475-484

[4] STEREOCONTROLLED SYNTHESIS OF SIALYL LEX, THE OLIGOSACCHARIDE BINDING LIGAND TO ELAM-1 (SIALYL = N-ACETYLNEURAMIN) [J].

NICOLAOU, KC ;

HUMMEL, CW ;

BOCKOVICH, NJ ;

WONG, CH .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (13) :870-872

[5] ELAM-1 MEDIATES CELL-ADHESION BY RECOGNITION OF A CARBOHYDRATE LIGAND, SIALYL-LEX [J].

PHILLIPS, ML ;

NUDELMAN, E ;

GAETA, FCA ;

PEREZ, M ;

SINGHAL, AK ;

HAKOMORI, SI ;

PAULSON, JC .

SCIENCE, 1990, 250 (4984) :1130-1132

[6] ADHESION RECEPTORS OF THE IMMUNE-SYSTEM [J].

SPRINGER, TA .

NATURE, 1990, 346 (6283) :425-434

[7] CELL-ADHESION - STICKY SUGARS FOR SELECTINS [J].

SPRINGER, TA .

NATURE, 1991, 349 (6306) :196-197

[8] CARBOHYDRATE LIGANDS FOR ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE-1 [J].

TIEMEYER, M ;

SWIEDLER, SJ ;

ISHIHARA, M ;

MORELAND, M ;

SCHWEINGRUBER, H ;

HIRTZER, P ;

BRANDLEY, BK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1138-1142

[9] RECOGNITION BY ELAM-1 OF THE SIALYL-LEX DETERMINANT ON MYELOID AND TUMOR-CELLS [J].

WALZ, G ;

ARUFFO, A ;

KOLANUS, W ;

BEVILACQUA, M ;

SEED, B .

SCIENCE, 1990, 250 (4984) :1132-1135

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