A NOVEL ROUTE TO THE 4-ANILIDO-4-(METHOXYCARBONYL)PIPERIDINE CLASS OF ANALGETICS

被引：35

作者：

FELDMAN, PL

BRACKEEN, MF

机构：

[1] Glaxo Research Laboratories, Five Moore Drive, North Carolina 27709, Research Triangle Park

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 13期

关键词：

D O I：

10.1021/jo00300a047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[No abstract available]

引用

页码：4207 / 4209

页数：3

共 16 条

[1] NEW 4-(HETEROANILIDO)PIPERIDINES, STRUCTURALLY RELATED TO THE PURE OPIOID AGONIST FENTANYL, WITH AGONIST AND OR ANTAGONIST PROPERTIES [J].

BAGLEY, JR ;

WYNN, RL ;

RUDO, FG ;

DOORLEY, BM ;

SPENCER, HK ;

SPAULDING, T .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (03) :663-671

[2] STRUCTURE-ACTIVITY STUDIES OF FENTANYL [J].

CASY, AF ;

HUCKSTEP, MR .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1988, 40 (09) :605-608

[3] SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF 4,4-DISUBSTITUTED PIPERIDINES [J].

COLAPRET, JA ;

DIAMANTIDIS, G ;

SPENCER, HK ;

SPAULDING, TC ;

RUDO, FG .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (05) :968-974

[4] SYNTHESIS OF BETA,GAMMA-UNSATURATED AMINO-ACIDS BY THE STRECKER REACTION [J].

GREENLEE, WJ .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (14) :2632-2634

[5] USEFUL SYNTHESIS OF ALPHA-AMINONITRILES BY MEANS OF ALUMINA AND ULTRASOUND [J].

HANAFUSA, T ;

ICHIHARA, J ;

ASHIDA, T .

CHEMISTRY LETTERS, 1987, (04) :687-690

[6]

HARUSAWA S, 1979, TETRAHEDRON LETT, P4663

[7]

JANSEN PAJ, 1976, Patent No. 3998834

[8] SYNTHETIC 1,4-DISUBSTITUTED-1,4-DIHYDRO-5H-TETRAZOL-5-ONE DERIVATIVES OF FENTANYL - ALFENTANIL (R-39209), A POTENT, EXTREMELY SHORT-ACTING NARCOTIC ANALGESIC [J].

JANSSENS, F ;

TORREMANS, J ;

JANSSEN, PAJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2290-2297

[9] 4-PHENYL-4-ANILIDOPIPERIDINES AND 4-HETEROARYL-4-ANILIDOPIPERIDINES - A NOVEL CLASS OF ANALGESIC AND ANESTHETIC AGENTS [J].

KUDZMA, LV ;

SEVERNAK, SA ;

BENVENGA, MJ ;

EZELL, EF ;

OSSIPOV, MH ;

KNIGHT, VV ;

RUDO, FG ;

SPENCER, HK ;

SPAULDING, TC .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (12) :2534-2542

[10] A FAST N-SUBSTITUTED ALPHA-AMINONITRILE SYNTHESIS [J].

MAI, K ;

PATIL, G .

SYNTHETIC COMMUNICATIONS, 1985, 15 (02) :157-163

← 1 2 →