EFFECTIVE BLOCKING OF HIV-1 PROTEINASE ACTIVITY BY CHARACTERISTIC INHIBITORS OF ASPARTIC PROTEINASES

被引：167

作者：

RICHARDS, AD

ROBERTS, R

DUNN, BM

GRAVES, MC

KAY, J

机构：

[1] UNIV WALES COLL CARDIFF,DEPT BIOCHEM,POB 903,CARDIFF CF1 1ST,WALES

[2] UNIV FLORIDA,J HILLIS MILLER HLTH CTR,DEPT BIOCHEM & MOLEC BIOL,GAINESVILLE,FL 32610

[3] HOFFMANN LA ROCHE INC,ROCHE RES CTR,DEPT MOLEC GENET,NUTLEY,NJ 07110

来源：

FEBS LETTERS | 1989年 / 247卷 / 01期

关键词：

D O I：

10.1016/0014-5793(89)81251-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：113 / 117

页数：5

共 22 条

[1] 2-STEP AFFINITY-CHROMATOGRAPHIC PURIFICATION OF CATHEPSIN-D FROM PIG MYOMETRIUM WITH HIGH-YIELD [J].

AFTING, EG ;

BECKER, ML .

BIOCHEMICAL JOURNAL, 1981, 197 (02) :519-522

[2]

BILLICH S, 1988, J BIOL CHEM, V263, P17905

[3] ON THE RATIONAL DESIGN OF RENIN INHIBITORS - X-RAY STUDIES OF ASPARTIC PROTEINASES COMPLEXED WITH TRANSITION-STATE ANALOGS [J].

BLUNDELL, TL ;

COOPER, J ;

FOUNDLING, SI ;

JONES, DM ;

ATRASH, B ;

SZELKE, M .

BIOCHEMISTRY, 1987, 26 (18) :5585-5590

[4] THE PH-DEPENDENCE OF THE HYDROLYSIS OF CHROMOGENIC SUBSTRATES OF THE TYPE, LYS-PRO-XAA-YAA-PHE-(NO2)PHE-ARG-LEU, BY SELECTED ASPARTIC PROTEINASES - EVIDENCE FOR SPECIFIC INTERACTIONS IN SUBSITES S3 AND S2 [J].

DUNN, BM ;

VALLER, MJ ;

ROLPH, CE ;

FOUNDLING, SI ;

JIMENEZ, M ;

KAY, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1987, 913 (02) :122-130

[5]

ELLIS KJ, 1982, METHOD ENZYMOL, V87, P405

[6]

GIAM CZ, 1988, J BIOL CHEM, V263, P14617

[7] AN 11-KDA FORM OF HUMAN IMMUNODEFICIENCY VIRUS PROTEASE EXPRESSED IN ESCHERICHIA-COLI IS SUFFICIENT FOR ENZYMATIC-ACTIVITY [J].

GRAVES, MC ;

LIM, JJ ;

HEIMER, EP ;

KRAMER, RA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (08) :2449-2453

[8] PARTIAL-PURIFICATION AND SUBSTRATE ANALYSIS OF BACTERIALLY EXPRESSED HIV PROTEASE BY MEANS OF MONOCLONAL-ANTIBODY [J].

HANSEN, J ;

BILLICH, S ;

SCHULZE, T ;

SUKROW, S ;

MOELLING, K .

EMBO JOURNAL, 1988, 7 (06) :1785-1791

[9] THE EFFECTS OF LACTOYL-PEPSTATIN AND THE PEPSIN INHIBITOR PEPTIDE ON PIG CATHEPSIN-D [J].

KAY, J ;

AFTING, EG ;

AOYAGI, T ;

DUNN, BM .

BIOCHEMICAL JOURNAL, 1982, 203 (03) :795-797

[10] INTERACTION OF HUMAN CATHEPSIN-D WITH INHIBITOR PEPSTATIN [J].

KNIGHT, CG ;

BARRETT, AJ .

BIOCHEMICAL JOURNAL, 1976, 155 (01) :117-125

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