ACCESSORY PROTEIN FUNCTION IN THE DNA POLYMERASE-III HOLOENZYME FROM ESCHERICHIA-COLI

被引：21

作者：

ODONNELL, M

机构：

[1] Howard Hughes Medical Institute, Microbiology Department, Cornell University Medical College, New York, New York, 10021

来源：

BIOESSAYS | 1992年 / 14卷 / 02期

关键词：

D O I：

10.1002/bies.950140206

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.

引用

页码：105 / 111

页数：7

共 38 条

[1] MOLECULAR ANALYSIS OF THE RECF GENE OF ESCHERICHIA-COLI [J].

BLANAR, MA ;

SANDLER, SJ ;

ARMENGOD, ME ;

REAM, LW ;

CLARK, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (15) :4622-4626

[2] PROGRAMMED RIBOSOMAL FRAMESHIFTING GENERATES THE ESCHERICHIA-COLI DNA POLYMERASE-III GAMMA SUBUNIT FROM WITHIN THE GAMMA-SUBUNIT READING FRAME [J].

BLINKOWA, AL ;

WALKER, JR .

NUCLEIC ACIDS RESEARCH, 1990, 18 (07) :1725-1729

[3]

BURGERS PMJ, 1983, J BIOL CHEM, V258, P7669

[4] THE DNAN GENE CODES FOR THE BETA-SUBUNIT OF DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI [J].

BURGERS, PMJ ;

KORNBERG, A ;

SAKAKIBARA, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5391-5395

[5]

BURGERS PMJ, 1982, J BIOL CHEM, V257, P1474

[6]

BURGERS PMJ, 1982, J BIOL CHEM, V257, P1468

[7] REPLICATION TIME OF ESCHERICHIA-COLI-K12 CHROMOSOME AS A FUNCTION OF CELL DOUBLING TIME [J].

CHANDLER, M ;

BIRD, RE ;

CARO, L .

JOURNAL OF MOLECULAR BIOLOGY, 1975, 94 (01) :127-131

[8]

DEFRANCESCO R, 1984, Journal of Biological Chemistry, V259, P5567

[9]

FAY PJ, 1981, J BIOL CHEM, V256, P976

[10] THE GAMMA-SUBUNIT OF DNA POLYMERASE-III HOLOENZYME OF ESCHERICHIA-COLI IS PRODUCED BY RIBOSOMAL FRAMESHIFTING [J].

FLOWER, AM ;

MCHENRY, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (10) :3713-3717

← 1 2 3 4 →