MURINE INTERLEUKIN-2 RECEPTOR BETA-CHAIN - DYSREGULATED GENE-EXPRESSION IN LYMPHOMA LINE EL-4 CAUSED BY A PROMOTER INSERTION

被引：106

作者：

KONO, T

DOI, T

YAMADA, G

HATAKEYAMA, M

MINAMOTO, S

TSUDO, M

MIYASAKA, M

MIYATA, T

TANIGUCHI, T

机构：

[1] TOKYO METROPOLITAN INST MED SCI,BUNKYO KU,TOKYO 113,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT BIOL,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 05期

关键词：

D O I：

10.1073/pnas.87.5.1806

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The functional, high-affinity interleukin 2 receptor (IL-2R) consists of at least two receptor components, IL-2Rα (p55) and IL-2Rβ (p70-75). The cDNA encoding the murine IL-2Rβ has been ed by using the previously cloned cDNA for human IL-2Rβ as a probe. Analysis of the cDNA revealed that the murine IL-2Rβ shows a marked homology with the human IL-2Rβ and that it is also structurally related to other cytokine receptors such as erythropoietin receptor. The cDNA-directed murine IL-2Rβ formed high-affinity IL-2R in conjunction with the endogenous IL-2Rα in a murine pro-B-cell line and could transduce IL-2-induced growth signal. In mouse lymphoma line EL-4, the IL-2Rβ gene was found to be rearranged by the insertion of the long terminal repeat sequence of an intracisternal A particle, giving rise to constitutive expression of the IL-2Rβ mRNA.

引用

页码：1806 / 1810

页数：5

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