HISTOCHEMICAL STUDY OF DRUG EFFECTS ON MICE INFECTED WITH TRICHINELLA SPIRALIS

Histochemical studies on the effect of (2[4''-thiazolyl]-benzimidazole) (Thiabendazole) and O,O,-dimethyl-2,2,2-trichloro-l-hydroxy-methyl phosphonate (Neguvon) administered subcutaneously on the muscular tissue of healthy and Trichinella spiralis-infected mice were performed. The changes suggested an inhibition in the metabolism of the muscle tissue, reduced activity of alkaline phosphatase, succinic acid dehydro-genase, and "a" phosphorylase. The parasite also caused changes such as a decrease in ATPase and "a"-phosphorylase activity. These drugs also inhibited glycogen synthesis in the larvae and caused a reduction in their RNA content.