STRUCTURAL CHARACTERIZATION OF HEMOGLOBIN TACOMA

被引：42

作者：

BRIMHALL, B

JONES, RT

BAUR, EW

MOTULSKY, AG

机构：

[1] Division of Experimental Medicine, Department of Biochemistry, University of Oregon Medical School, Portland

[2] Division of Research, Department of Institutions, Fort Steilacoom

[3] Departments of Medicine and Genetics, University of Washington, Seattle

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 05期

关键词：

D O I：

10.1021/bi00833a051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chemical characterization of hemoglobin Tacoma demonstrates a single substitution of a seryl residue for the arginyl residue number 30 of the α chain. Because this appears to be the only substitution in the abnormal hemoglobin, the structural formula is α2β230Ser. This substitution occurs in a region of residues 28-42 which is one of the relatively invariant parts of the β chain of normal animal hemoglobins. © 1969, American Chemical Society. All rights reserved.

引用

页码：2125 / &

共 20 条

[1] Protein coagulation and its reversal - The preparation of insoluble globin, soluble globin and heme [J].

Anson, ML ;

Mirsky, AE .

JOURNAL OF GENERAL PHYSIOLOGY, 1930, 13 (04) :469-476

[2] AN IMPROVED METHOD FOR FINGERPRINTING OF HUMAN HEMOGLOBIN [J].

BAGLIONI, C .

BIOCHIMICA ET BIOPHYSICA ACTA, 1961, 48 (02) :392-&

[3] ABNORMAL HUMAN HEMOGLOBINS .X. A STUDY OF HEMOGLOBIN LEPOREBOSTON [J].

BAGLIONI, C .

BIOCHIMICA ET BIOPHYSICA ACTA, 1965, 97 (01) :37-&

[4]

BAUR EW, 1965, HUMANGENETIK, V1, P621

[5] REACTION OF CYANOGEN BROMIDE + N-BROMOSUCCINAMIDE WITH SOME CYTOCHROMES C [J].

CHU, RCL ;

YASUNOBU, KT .

BIOCHIMICA ET BIOPHYSICA ACTA, 1964, 89 (01) :148-&

[6] ABNORMAL HUMAN HAEMOGLOBINS - SEPARATION AND CHARACTERIZATION OF ALPHA AND BETA CHAINS BY CHROMATOGRAPHY AND DETERMINATION OF 2 NEW VARIANTS HB CHESAPEAKE AND HB J (BANGKOK) [J].

CLEGG, JB ;

NAUGHTON, MA ;

WEATHERA.DJ .

JOURNAL OF MOLECULAR BIOLOGY, 1966, 19 (01) :91-&

[7] HAEMOGLOBIN HAMMERSMITH (BETA 42 (CDI) PHE-]SER) [J].

DACIE, JV ;

SHINTON, NK ;

GAFFNEY, PJ ;

CARRELL, RW ;

LEHMANN, H .

NATURE, 1967, 216 (5116) :663-&

[8]

GUEST JR, 1967, J BIOL CHEM, V242, P5397

[9] ABNORMAL HUMAN HAEMOGLOBINS .1. THE COMPARISON OF NORMAL HUMAN AND SICKLE-CELL HAEMOGLOBINS BY FINGERPRINTING [J].

INGRAM, VM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1958, 28 (03) :539-545

[10] STRUCTURAL STUDIES OF AMINOETHYLATED HEMOGLOBINS BY AUTOMATIC PEPTIDE CHROMATOGRAPHY [J].

JONES, RT .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1964, 29 :297-&

← 1 2 →